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Pitt-UPMC researchers will use $5 million from Bayer to fight chronic kidney disease

Manisha Jhamb smiling in grey suit outside

One in seven American adults 鈥 37 million people 鈥 have chronic kidney disease (CKD), an incurable condition with few treatments available to slow its progression or delay organ failure.

听(pictured), an associate professor and associate chief of the renal-electrolyte division in Pitt鈥檚 Department of Medicine, wants to make sure that the small number of existing treatments get to the right people 鈥 especially those in rural areas without access to nephrologists.

Her new five-year study will use real-world data to determine how an approach called population health management can close gaps in care delivery for CKD patients. A $5 million research collaboration with Bayer pharmaceuticals is making the work possible. 听

Population health management looks at members in a health system, such as UPMC where Jhamb is also a nephrologist, and builds algorithms to predict which patients might be at high risk for certain chronic diseases or poor outcomes, or which patients might qualify for a certain drug. It then alerts the patient鈥檚 primary care doctor (PCP) and suggests a referral to the appropriate specialist.

鈥淚t鈥檚 a very new way of doing things,鈥 said Jhamb, adding that few academic medical centers in the country have health care delivery systems that can pull off testing this integrated approach to health care.

The PCP is usually a patient鈥檚 first stop for treatment of CKD, so it鈥檚 a logical moment to make sure patients are getting timely and up-to-date care. 鈥淲e are providing resources to PCPs to inform care for these patients and help them implement the latest guidelines,鈥 said Jhamb.

After the alert, the patient can opt for remote care delivery co-managed by a nephrologist and their PCP, alleviating the burden of having to physically see additional specialists.

鈥淭his way, we are working to engage patients earlier in the course of their illness, leading to improved outcomes,鈥 said Jhamb. The approach can be particularly helpful for PCPs who are trying to manage a patient鈥檚 chronic kidney disease with few specialists nearby.

Jhamb and her team also offer an array of resources to patients who are at high risk for kidney disease and aren鈥檛 already getting nephrology care. The resources, which can be provided entirely remotely at no cost to the patient, include nephrologist recommendations, a medication review by a pharmacist and education from a nurse-educator.

鈥淎nd it鈥檚 aligned with the PCP鈥檚 workflow, so it minimizes a lot of barriers at the PCP level and at the patient level,鈥 Jhamb added.

Said Todd Williamson, vice president of data generation and observational studies at Bayer, about the novel process: 鈥淯nderstanding the impact that CKD progression has on patients, as well as the benefits of earlier identification and management, is important to document the potential benefits of a program like this in real world patient management.鈥

鈥淭here are not enough nephrologists to take care of everybody with chronic disease,鈥 said Jhamb. 鈥淏ut we want to make sure we can come up with a strategy that is scalable, that is resource efficient, to empower PCPs. I think it鈥檚 just a huge win for everyone,鈥 she said.

Jhamb was also recently named the director of Pitt鈥檚 new Center for Population Health Management, funded by the 麻豆传媒鈥檚 Department of Medicine, which is dedicated to applying this new health care delivery approach to other chronic diseases such as obesity and diabetes.

鈥 Micaela Corn, photo by Tom Altany