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Philadelphia has its pharmaceutical cluster, San Francisco is known for its tech startups and Boston boasts about its investment capital. Thanks to efforts by the �鶹��ý, fueled by a $25 million gift from the Henry L. Hillman Foundation, Pittsburgh is enhancing its role as a premier life sciences cluster.

The gift, announced this week, will support focused biomedical research, develop collaborations through virtual spaces and physical infrastructure, build systems for new and growing life sciences companies and drive inclusive workforce development.

“This gift is an investment in the �鶹��ý but also in the people and potential of our region,” �鶹��ý Chancellor Patrick Gallagher said. “It will drive innovations in vision care and—even more—fuel Pittsburgh’s rise as a world leader in life sciences research.”   

This work requires a strategic alignment of facilities and resources, investment in specialized laboratories and leadership, and close coordination among key faculty, entrepreneurs and community stakeholders. Through such partnership and investment, Southwestern Pennsylvania will become a hotbed for world-renowned patient access and care, new discoveries and commercialization, area leaders said.

“Dating back to the 1960s, the Henry L. Hillman Foundation has directed much of its attention to advancing quality of life in the region,” said foundation president David Roger. “Pittsburgh stands in a unique position to lead the world in life sciences, and this grant will help shape a corridor that will drive the post-pandemic economy and create breakthrough discoveries—to the benefit of the region’s residents—for decades to come.”

Pitt already is investing heavily in growing life sciences research and education, including bringing crucial faculty and staff to the UPMC Vision and Rehabilitation Tower, funded by UPMC, rising in Pittsburgh’s Uptown neighborhood.

The Henry L. Hillman Foundation gift will, among other efforts, improve access to vision care for underserved communities through outreach and direct care; help build and staff a vision “street lab” to test new treatments and therapies in safe, controlled, virtual and real-life environments; and support research into breakthrough programs such as biomedical solutions to corneal blindness. The gift will also fund commercialization efforts and will, in turn, create job and training opportunities for adjacent neighborhoods and the city with an emphasis on promoting equitable access to services and employment.

In all, $20 million of the gift will fund vision care research and development through The Eye & Ear Foundation, which supports Pitt’s Departments of and by advancing leading-edge academics and research to enhance patient care. As a result of the gift, The Eye & Ear Foundation has passed the halfway point in its campaign to support vision restoration breakthroughs, advance technologies and therapies addressing vision loss, lower barriers to healthcare for all Pittsburghers, and fuel the growth of the city’s burgeoning biotech sector.

José‐Alain Sahel, who from Paris’ Institut de la Vision at Sorbonne University to direct the Department of Ophthalmology, will lead the vision work made possible by the Henry L. Hillman Foundation gift.

“We are driven by helping patients,” Sahel said. “It starts with identifying conditions among patients, which flows into using research to find solutions, creating new therapies and devices, commercializing those advancements and ultimately bringing them back to the patient by enabling access to everyone.”

“No one person can do this,” he added. “It takes teams of clinicians, scientists, educators, rehabilitation experts and patients themselves all looking at questions that have not been solved. Only then can you develop answers.”

Vision degeneration affects nearly everyone in one form or another as they age, and the number of individuals with visual impairments is expected to triple by 2050. Pittsburgh, with its aging population, will be highly affected by this epidemic of vision loss. Finding cures for the most common eye ailments and solutions to rare diseases and impairment due to injury are equally important, Sahel said. His teams are working on , from common conditions such as glaucoma and macular degeneration to regenerative therapies and and the hardware and software that feeds them information.

Further supporting an equitable regional economy, the Hillman gift includes funding for vision-related workforce development—training local residents to fill jobs created by the overall project. It also provides seed funding for breakthrough research with high potential for commercialization and emerging startups working in the sector.

Along with the vision-focused work, $1 million of the gift will support further life sciences planning under the direction of Anantha Shekhar, senior vice chancellor for the health sciences and John and Gertrude Petersen Dean of the at the �鶹��ý. Another $3 million is allocated to supporting the LifeX startup accelerator, and $1 million will go to vaccine research.